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The general notion of impaired experience-dependent plasticity in Angelman syndrome is reinforced by the observation that MD, which usually induces an OD shift in the visual cortex of wild type mice, does not have such an effect in Ube3a -deleted animals (Yashiro et al., 2009)

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Mammalian cells express two isoforms of GLS: kidney-type GLS1 and liver-type GLS2

Dopamine -hydroxylase is a major vitamin C and copper (Cu 2+ )-dependent enzyme whose activity is negatively affected in Menkes disease

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