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In addition to detoxifying exogenous aldehydes, ALDH2 serves a key role in eliminating endogenous aldehydes generated during oxidative stress, including 4-hydroxy-2-nonenal (4-HNE), malondialdehyde (MDA) and acrolein (29,30)

A similarly high incidence of OS was reported in a recent clinical trial, with 83.8% (124 of 148 cases) of idiopathic infertile men having positive seminal oxidation-reduction potential (ORP), a measure of ROS-antioxidant discrepancy [unpublished data]

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Cytidine Deaminase Polymorphism Predicts Toxicity of Gemcitabine-Based Chemotherapy

An epidemic of DM is underway as result of population growth and aging, increased urbanization, prevalence of obesity and sedentary lifestyle [1]