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934 Recent studies have shown increased expression of elabela and APJ in neurons after cerebral I/R injury, with typical morphological and molecular features associated with ferroptosis in neurons, such as mitochondrial shrinkage, iron, and MDA accumulation, upregulation of ACSL4 and ALOX15, and downregulation of GPX4 and xCT

Murphy, Klaus-Armin Nave, Tal Nuriel, Stphane H

Specifically, Astragalus membranaceus polysaccharides can increase the abundance of beneficial bacteria, such as Bifidobacterium and Lactobacillus, while reducing harmful bacteria like Shigella [104,105,106]

It is made entirely in a lab using solid-phase peptide synthesis a chemical process that builds peptides one amino acid at a time on a polymer resin

However, whether a similar p53SLC7A11 regulatory mechanism contributes to ferroptosis susceptibility in OA chondrocytes remains unclear and requires further investigation (85)