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The redox status has been suggested to regulate stem cell self-renewal and differentiation, and accumulating evidence indicates that stem cells undergo self-renewal in the environment with low ROS levels, while ROS levels increase in differentiated stem cells [117, 118]

The role of PARP and the use of PARP inhibitors in parthanatos have been considered above

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However, due to the strong metastatic characteristics of lung cancer and the emergence of related drug resistance and radiation resistance, the overall survival rate of lung cancer patients is not ideal

The G-SH cleavage by GGT leads to the production of cysteinyl-glycine dipeptide, which retains the thiol group and is a more reactive and stronger reducing agent than G-SH [14]