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showed that SB administration (1 g/kg/d) inhibited the activation of the cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) pathway in a HDAC5/HDAC6-dependent manner, contributing to reducing Ang II-induced heart hypertrophy, mean arterial pressure and inflammation (Zhang et al., 2019)

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Fahey JW, Wade KL, Stephenson KK, Shi Y, Liu H, Panjwani AA, Warrick CR, Olson ME

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PMID: 29176489 Fehlings, M.G., Kim, K.D., Aarabi,B., Rizzo, M., Bond, L.M., McKerracher, L., Vaccaro A.R.., Okonkwo, D.O.: Rho Inhibitor VX-210 in Acute Traumatic Subaxial Cervical Spinal Cord Injury: Design of the Spinal Cord Injury Rho Inhibition Investigation (SPRING) Clinical Trial

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