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Key Points Hereditary hemochromatosis is a common genetic disorder that has various forms and is easy to diagnose Although the different forms of hereditary hemochromatosis have similar phenotypes, they are caused by different genetic defects Patients with hereditary hemochromatosis produce reduced amounts of the master regulator of iron homeostasis, hepcidin, resulting in increased dietary iron absorption and accumulation in tissues If untreated, hereditary hemochromatosis can result in progressive organ failure and death, whereas early initiation of treatment is associated with a normal life expectancy Genetic and environmental factors can modify the clinical penetrance and severity of hereditary hemochromatosis This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access 186,36 per year only 15,53 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

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After reducing the supernatant to 4 C overnight, the crystals underwent filtration in preparation for lyophilization