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This difference must reflect divergence between the radical removal and redox systems or the enzyme cofactor requirements of eukaryotes and prokaryotes, unless the latter have an unidentified substitute reductone

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Dabrafenib treatment significantly upregulated the expression of Axl receptor tyrosine kinase (Axl) in the spinal cord tissues of EAE mice, increased the expression of System Xc , GPX4, and Ferritin, and decreased the expression of CD71, ACSL4, and POR

The ferroptosis activator RSL-3 and the PI3K/Akt pathway inhibitor LY294002 reversed Neuritins inhibitory effect on ferroptosis, indicating that Neuritin suppresses neuronal ferroptosis via PI3K/Akt pathway activation (Song et al., 2025)