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Blood pressure improvements were observed across prespecified subgroups including participants with and without baseline hypertension
Beyond vascular [79,80] and immune functions [81,82,83], NO contributes to central and peripheral sensitization by modulating excitatory neurotransmission and interacting with cyclic GMP pathways [84,85,86]
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The PCACs role is advisory: it provides recommendations to FDA, but does not make binding decisions
