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Moreover, the pentaspan membrane glycoprotein prominin-2 promotes ferroptosis resistance by facilitating the formation of ferritin-containing multivesicular bodies (MVBs) that transport iron out of a cell [33]

Studies have shown that when amyloid-beta and tau are increased, the cells ability to neutralize oxidative stress and mitochondria specific ROS is decreased leading to further tau hyperphosphorylation and neurodegeneration (Alavi Naini and Soussi-Yanicostas 2015)