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Journal of Cosmetic Dermatology, June 2019, pages 728-737 4

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397 In a Phase II trial (NCT02420314) for advanced NSCLC, Ascorbate combined with Carboplatin and Paclitaxel inhibited tumor growth through HO generation, iron modulation (higher transferrin linked to improved PFS), and immune activation (4.2-fold increase in CD8 + T cells), achieving a 34.2% response rate and a 12.8-month median OS

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Fever, chills, and redness, pus or spreading warmth at the site can indicate cellulitis or a bloodstream infection and need medical attention