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Description
First-in-human phase I study of EZN-4176, a locked nucleic acid antisense oligonucleotide (LNA-ASO) to androgen receptor (AR) mRNA in patients with castration-resistant prostate cancer (CRPC)
Lysine is critical because its -amino groups are usually solvent-exposed on protein surfaces, making them accessible for bioconjugation

(2021) 53:e14193
Comparison of the effects of acetyl L-carnitine and amantadine for the treatment of fatigue inmultiple sclerosis: results of a pilot, randomised, double-blind, crossover trial

10.1002/jha2.342 Sion Scott, Helen May, Martyn Patel, David J Wright, Debi Bhattacharya
