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Different sources of MSCs have also been found to have differences in their immunological characteristics, as well as have different paracrine signaling and immune modulation abilities 92

The correspondence between higher RRM2 expression and N stage further reinforces this notion

In vivo coengrafting of ROCK-educated fibroblasts with tumor cells accelerates tumor growth, demonstrating that CRELD2 is both necessary and sufficient to drive a tumor-supportive fibroblast phenotype
