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This suggests that although all the SRD5A family members use NADPH as the cofactor to reduce their substrates, they have evolved specific structural features to recognize different steroid or lipid substrates 1,7

Li P, Zhang HJ, Zheng LT

10.1038/s41575-021-00440-6 386 SampsonT

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d , Immunoblot analysis of indicated proteins from KPK cells expressing sgRNA targeting intergenic region or sgRNA targeting Slc33a1
