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Additional dose groups (including higher single-dose ranges) have been discussed in regulatory/nomination documents
Vidal-Alaball et al., 2006)

Advanced protocol: Some researchers use up to 2.5 to 3 mg weekly, though evidence supporting additional benefit from higher doses remains limited while side effect potential increases
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Pentadeca Arginate has demonstrated potential in reversing opioid tolerance, allowing patients to achieve effective pain relief with lower doses of opioids