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Cancer cells exhibit particularly high iron requirements to support their rapid growth, and consequently, they are well adapted for acquiring iron and preventing its loss [98]

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On the other hand, exclusion criteria included (1) review articles with poor experimental data, (2) research studies without clear methodologies, (3) research articles unrelated to pharmaceutical prospect of antioxidants and (4) publications without scope of our research work, (5) non-peer-reviewed studies, (6) literature older than 25 years, as well as (6) unpublished work

As aforementioned, metastatic cells especially those enriched with CSCs are more vulnerable to pro-oxidative regimen that can easily penetrate through the multi-cell layer within the TME and reach tumor cells