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Within the locus coeruleus (a brainstem nucleus in the dorsal pontine tegmentum) the end product of the pathway is norepinephrine
A newer analysis of two multi-center clinical studies of subjects with type I or type II diabetes showed that oral treatment with acetyl-L-carnitine (3000 mg/day) over a period of one year provided significant relief from nerve pain as well as improved vibration perception in patients with diabetic neuropathy
doi: 10.1161/CIRCRESAHA.116.303587 121 LiuMHanQYangJ
