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The MUT enzyme plays a critical role in the catabolic breakdown of odd-chain fatty acids, cholesterol, and certain branched-chain amino acids (like isoleucine and valine)

When NNMT activity is dialed down, it allows for increased levels of nicotinamide adenine dinucleotide (NAD+), a coenzyme absolutely critical for countless metabolic processes, including energy production and cellular repair

Each subject may experience varying results depending on their age, diet, level of exercise, genetics, and other lifestyle factors

and inferior to systemic glucocorticoids with an improved safety profile for both indications[1,24,3537]

In particular, B12 and B9 deficiencies can cause neural tube defects, which can prevent the spinal cord or brain from developing properly