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Hyperammonemic encephalopathy : May cause obtundation and seizures (with the potential to progress to coma and death)

The species studied included Sprague-Dawley rats, CD-1 mice, Beagle dogs, and cynomologus monkeys treated with-naphthoflavone or phenobarbital (all species), isoniazid (rat), pyrasole (monkey), dexamethasone (rat, mouse, monkey), rifampin (dog), or clofibric acid (rat, mouse, dog)

[DOI] [PubMed] [Google Scholar] Nicholls S.J., Lincoff A.M., Garcia M., Bash D., Ballantyne C.M., Barter P.J., Nissen S.E

Durata administrarii 3 luni, urmata de o pauza de o luna, dupa care se poate relua administrarea produsului
