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This may be due to compensatory action of other antioxidant enzymes, since expressions of TRX, other members of PRX family and CAT were all upregulated in response to PRX-2 inhibition (Won et al

Notably, antioxidants like N-acetyl cysteine (NAC) and polyphenols counteract these effects, emphasizing the potential therapeutic implications (72)

The fractions were dissolved in deuterated methanol to achieve 30 mg/mL and put in NMR tubes (Cortec Net, Les Ulis, France)

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Grape polyphenols prevent fructose-induced oxidative stress and insulin resistance in first-degree relatives of type 2 diabetic patients