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Some studies suggest that babies born to B12-deficient mothers may experience delays in speech, memory, and attention during early childhood [*]

For patients with clinical deficiency, effective replacement therapy should lead to a normal blood count after two months of treatment, while improvement in neurologic symptoms begins within one week after initiation of therapy and is usually complete within 6 weeks to 3 months.13 For patients with an asymptomatic biochemical deficiency (ie, subclinical disease), measurement of serum B12 or MMA levels should be done 2 to 3 months after initiation of replacement therapy.12 Once metformin is started, this medication is seldom discontinued unless advanced renal impairment develops

B12 Injections Before we discuss the safety of administering B12 injections at home, lets briefly touch on the benefits of oral B12 supplements compared to injections: 1