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Given the complexity of AD, a comprehensive prevention and control strategy may be more effective than single-target intervention

The nuclear respiratory factors (Nrf1 and Nrf2) that initiate the transcription of genes linked to mitochondrial biogenesis are co-activated by SIRT1 through the activation and deacetylation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1) (Scarpulla, 2011), a master regulator of mitochondrial biogenesis

This proximity induces caspase-1 autocleavage and activation, enabling downstream processing of proinflammatory cytokines [34]

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Trans Am Ophthalmol Soc (2015) 113:T12