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3.3.3 Other inhibitors Serine hydroxymethyltransferase (SHMT), a pivotal enzyme in one-carbon metabolism, catalyzes the conversion of serine and tetrahydrofolate (THF) to glycine and 5,10-methylenetetrahydrofolate (5,10-CH 2 -THF), providing one-carbon units for nucleotide synthesis
Dang, Y
