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Furthermore, melatonin indirectly combats free radicals by chelating metal ions in the brain [148]

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Further mitochondria also have a role and are associated with cellular senescence, chronic inflammation (inflammaging), decline in innate immunity, and the age-dependent decline in stem cell activity [9] (Fig

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Interestingly, our proteomics data showed the same pattern of decreases in iron uptake proteins and pathways, as well as increases in proteins involved in iron storage, consistent with our RNA-seq results

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I acknowledge that all materials will be handled only by trained personnel familiar with laboratory procedures and potential risks

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