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Burke DG, Chilibeck PD, Davison KS, Candow DC, Farthing J, Smith-Palmer T

Journal of Photochemistry and Photobiology B: Biology

(2017) noted that patients with hepatic steatosis have depleted NAD+ and glutathione as a primary feature of the condition

However, in the presence of oxidative or nitrosative stress, GST can form homodimers that alter the reduced states of cysteine residues in its structure, resulting in JNK dissociation from the GSTJNK heterocomplex and causing subsequent activation of the c-Jun protein