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This signaling cascade not only governs gene transcription related to immune and inflammatory responses but is also modulated by metabolic inputs such as cholesterol levels and cellular stress signals

Consistent with their elevated SLC7A11 expression level, IRE1-null MDA-MB-231 cells also demonstrated increased cystine uptake, which can be inhibited by IRE1 reconstitution (Supplementary Fig

344 HIFU induces thermal ablation, effectively destroying tumor cells, whereas LIFU, combined with microbubbles, transiently disrupts the BBB, enhancing targeted drug delivery

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Participants also reported a mean 58% reduction in the use of SABA (155)