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Moisture can lead to peptide hydrolysis and degradation

The intracerebroventricular (ICV) injection of the DEETGE-Cal-Tat peptide showed an increased expression of Nrf2- regulated genes and marked neuroprotective and cognitive-preserving effects in mice subjected to brain injury [301]

Targeting glutamine metabolism to enhance immunoprevention of EGFR-driven lung cancer

Neuronal mitochondria are particularly vulnerable to oxidative damage because of the brain's high metabolic demands, rich lipid content, and relatively low antioxidant defenses compared to other tissues

In patients with severe hepatic or renal disease, effects of therapy should be followed with serial liver and/or renal function tests