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Financial support and sponsorship This work was supported by NIH grants R01HL169291 (to Lee RT), R35GM134923 and R01AG072087 (to Thompson TB), R01AG057428 and an award from the Glenn Foundation (to Wagers AJ), and R01AG072086 (to Rubin LL and Wagers AJ)

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Measurement of alcohol dehydrogenase (ADH) activity The ADH activity of the supernatant were measured using an Alcohol Dehydrogenase Assay kit (Abcam, Cambridge, UK)

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