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They warn that the lack of rigorous clinical trials and standardized protocols raise serious safety concerns, including the risk of hepatotoxicity (liver damage caused by chemicals) and allergic reactions like anaphylaxis

Kallner, A., Hartmann, D., & Hornig, D

10.1093/gerona/60.12.1510 49 JaW

You just run the water through an activated-carbon filter, which are cheap and widely produced
Their Phase 2 clinical trial found that xanthohumol, a natural compound from hops, moved patients with active Crohn's disease into remission within 4 weeks, with no adverse effects
