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The folate-cobalamin interaction is pivotal for normal synthesis of purines and pyrimidines and the transfer of the methyl group to cobalamin is essential for the adequate supply of tetrahydrofolate, the substrate for metabolic steps that require folate

The piriformis muscle can tighten up and put constant pressure against the sciatic nerve

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Furthermore, BAPPs can specifically bind to designated binding domains in GAG molecules via hydrogen bonds, van der Waals forces, and hydrophobic interactions [178]

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