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Because NNMT activity intersects methyl donor utilization and nicotinamide handling, experimental inhibition can be used to probe pathway level relationships among methyl economy balance, NAD+ salvage flux, and downstream metabolic signaling in a range of preclinical systems
Thinner on the legal-now core (no NAD+ or glutathione), and most protocols require a consult to get a quote
doi: 10.1016/j.biochi.2012.11.017 55
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