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272 Although the precise molecular mechanisms whereby vitamin B6 sensitizes malignant cells to adverse conditions remain unclear, we found that the administration of pyridoxine (i) facilitates the establishment of oxidative stress (presumably explaining the influence of vitamin B6 on tumor progression) 272 and (ii) promotes the intracellular accumulation of CDDP (at least in part accounting for the ability of vitamin B6 to promote the cytotoxicity of CDDP, in vitro and in vivo )
In this context, the development of new pharmacological therapies for the prevention and/or treatment of cataracts is essential to lessen the socio-economic burden and enhance patients quality of life
[27] as well as in our sample of participants with generally mild symptoms
Frontline therapy with high-dose imatinib vs
Colorimetric/fluorometric assay kits [Biovision Incorporated, Milpitas, USA] were used to measure aspartate aminotransferase (AST), alanine aminotransferase (ALT) and -glutamyltransferase (-GGT)
