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The vulnerability to ferroptosis is controlled by the oxidation of polyunsaturated lipids and the activity of related lipid metabolism enzymes
Targeting DNA methylation DNA methylation inhibitors have garnered considerable attention in oncological research owing to their potential to revise abnormal DNA methylation patterns linked to tumorigenesis
Furthermore, in CRC patients, an association between higher plasma IGF-2 levels and improved OS was observed, whereas loss of IGF-2 imprinting in stage IV CRC was linked to a worse OS [53]
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