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Intriguingly, this effect required continuous exposure to APAP, as animals fed APAP overnight (to simulate a brief/singular dose) showed a mild reduction in survival, but the reduction in survival was not as significant as those who experienced continuous exposure (Supplemental Fig

10.1016/j.nut.2013.10.00 10.1016/j.nut.2013.10.00 [DOI] [PubMed] [Google Scholar] Wang Y, Cui R, Xiao Y et al (2015) Effect of carotene and lycopene on the risk of prostate cancer: a systematic review and dose-response meta-analysis of observational studies

Ferroptosis can overcome the resistance of cancer cells to conventional therapies, especially in highly heterogeneous tumors such as glioblastoma and melanoma (121, 122)