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The toxicity is maintained when hydrophobic L-Leu at the first variable position is swapped out for another hydrophobic L-amino acid, such as alanine, phenylalanine, or tryptophan, but it is significantly reduced when a hydrophilic amino acid, such as arginine, is used in its place

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Magnesium and calcium Why not together: Although these two minerals work together, they must be in balance to be effective

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