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When cysteine residues in KEAP1 are oxidized by increasing levels of reactive molecules such as ROS and RNS, NRF2 is released allowing it to migrate to the nucleus and activate the expression of genes encoding proteins with cytoprotective functions

doi:10.1111/1471-0528.13574

Side Effects B12 injections are generally safe and well-tolerated

Furthermore, potential risks of immune-modulating treatment during pregnancy are not specific to FcRn antagonists, as illustrated by the need for patients with TED to stop treatment with corticosteroids and anti-thyroid drugs when planning a pregnancy [344]