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10.1016/j.phymed.2021.153694 187 YanB.BelkeD.GuiY.ChenY

Ursolic acid regulates key EMT transcription factors, induces cell cycle arrest and apoptosis in MDA-MB-231 and MCF-7 breast cancer cells, an in-vitro and in silico studies

Methods: A PRISMA-guided systematic review was conducted using PubMed and MEDLINE databases with search terms glutathione AND topical AND skin OR dermatology. From 446 articles, only clinical trials on topical glutathione were included, excluding reviews, animal studies, and research on oral or intravenous glutathione

Therefore, focus has been drawn towards targeting the glutathione antioxidant system in tumor cells as a therapeutic approach using drugs to target glutathione directly, indirectly, or by using glutathione-based prodrugs (Figure 4) [15]

Its involved in the bodys defense system, helping to neutralize harmful free radicals and eliminate toxins
