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2021 Nov;49(11):1441-1442
A functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-B signalling

Acetyl-carnitine is more easily absorbed from the gut, crosses the blood-brain barrier more readily, and as a bonus supplies acetate, which may boost mitochondrial metabolism both for energy and acetylcholine production

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The resulting glutamate overstimulation of NMDA and metabotropic glutamate receptors (mGluRs) further complicates the situation, whereby mGluR activation via phospholipase C (PLC) and inositol trisphosphate (IP 3 ) signaling prompts Ca 2+ overload [138]
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