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It is a requirement for meaningful results

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Due to the complexity, and size limitations associated with the cobalamins, the primary method for calculating ground state properties is density functional theory (DFT), while time-dependent DFT (TD-DFT) is used for electronically excited states

raised the possibility that T cell function in the tumor microenvironment can be enhanced by inhibition of CD38 and increased availability of NAD + (75)
