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Here, we systemically demonstrate that GDIL drives acquired platinum resistance by inhibiting GSH degradation instead of increasing GSH synthesis, through GDIL/XRN2/CHAC1 pathways

American Journal of Neuroradiology, 43 (1), 1118

De toxificerende (giftige) werking omvat de activering van vicinale dihaloalkanen onder vorming van een sterk reactieve episulfoniumring, alsook een door -Lyase mogelijk gemaakte verandering van het GSH-conjugaat in de nieren tot reactieve verbindingen

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TMB was used as an OH radicals detector, H 2 O 2 (31 M), FeSO 4 (33.2 M) were used to generate OH radicals