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32 For example, in breast cancer cells, the Fe 2 concentration in the LIP can reach 1015 M, whereas in normal breast epithelial cells, it is only 57 M, with the free Fe 2 levels being 1.52 times higher than in normal cells

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PKB/AKT enzymes also contain a plekstrin homology (PH) domain allowing them to be directly associated with the PI3K signal transduction pathway
