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In addition to the validation of established structural and organisational features of Retromer and Retriever and their known accessory proteins, our data-rich proximity proteomic resource provides a wealth of molecular details of endosomal cargo retrieval and recycling

DEM has been reported to produce a non-linear response to glutathione depletion, with a minor glutathione loss induced by DEM at 10100 M increasing lifespan via hormesis, but a major glutathione loss induced by DEM 1 mM shortening lifespan (Urban et al., 2017)

Human nestin (NES) marks tumor cells

Synergistic renoprotective effect of melatonin and zileuton by inhibition of ferroptosis via the AKT/mTOR/NRF2 signaling in kidney injury and fibrosis

Approaches such as intrathecal, intracerebroventricular, and intraparenchymal injections, as well as transient BBB disruption, have been employed to deliver drugs with limited CNS bioavailability (Ganger and Schindowski, 2018