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Rather than combining two separate compounds, tirzepatide is a single molecule engineered to activate two receptors simultaneously

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Oncoimmunology 7:e1391972 Ellerby HM, Arap W, Ellerby LM, Kain R, Andrusiak R, Rio GD, Krajewski S, Lombardo CR, Rao R et al (1999) Anti-cancer activity of targeted pro-apoptotic peptides