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Common Research Use Context

Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

So the two come from separate chemical families, and asking whether NAD is a peptide is a bit like asking whether a battery is a text message

Finally, its worth noting that aging itself disrupts circadian rhythms, but conversely, experimental circadian disruption (e.g., chronic jet-lag in animal models) can shorten lifespan and induce phenotypes of premature aging (Kumari et al., 2024