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This is consistent with the methyl folate trap hypothesis (54), which predicts that, in vitamin B-12 deficiency, the inhibition of DNA synthesis and cell proliferation is removed upon administration of high doses of folic acid because of increased availability of nonmethylated folate

To prevent this, standard guidelines mandate prophylactic administration of Rh(D) immune globulin at 28 weeks gestation and within 72 hours postpartum for all unsensitized Rh-negative mothers carrying an Rh-positive fetus

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Surgical Ligation The shunting vessel is identified by midline laparotomy and narrowed or completely occluded by a nonabsorbable ligature