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Cysteines with increased oxidation were labeled black

Glucosamine has been safely used for up to 2 years in some trials

Pattern of hereditary hemochromatosis: pronounced parenchymal siderosis (accumulation of hemosiderin within the tissue) in hepatocytes and bile duct epithelium Pattern of secondary iron overload: Kupffer cells (specialized macrophages) containing hemosiderin Presence and degree of hepatic fibrosis (see Pathophysiology in Cirrhosis) The use of liver biopsy in hemochromatosis is limited, as the concentration and distribution pattern of hepatic iron can be assessed using noninvasive MRI

This finding is clinically important because it supports a novel mechanism of action

[PubMed] 266: Micieli JA, Surkont M, Smith AF