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Proinflammatory cytokines play a key role in astrocytic transformation, promoting increased APP expression, -site APP cleaving enzyme 1 activity and secreted A levels, all of which are linked to neurodegenerative disease pathology 90

GLP-1 agonists, such as semaglutide, mimic the bodys natural incretin hormones, helping individuals feel fuller for longer and reducing overall caloric intake

Jiang Z, Rompala GR, Zhang S, Cowell RM, Nakazawa K

Gray, L

It has potential for CD treatment by repairing the intestinal barrier and alleviating intestinal inflammation via inhibiting ROS-mediated intestinal epithelial cell pyroptosis [133]
