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Currently, studies are being performed to address the above mentioned problems and have majorly focused on omic tools that take into consideration of ionomics (trace elements), metabolomics (metabolome), transcriptomics (transcriptome), and proteomics (proteome)

Detachment of cytochrome c from cardiolipin might also be triggered by increased cytosolic calcium, which weakens the electrostatic interaction between cytochrome c and cardiolipin and further generates ROS via MPT

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