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Rodent findings that mu-opioids and dopamine play functionally different roles in the hedonic and motivational properties of reward (Berridge, 2007) need further examination in humans

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Another example of an adverse interaction between aminoglycosides and phospholipid is the observation that gentamicin inhibits agonist activation of the phosphatidylinositol cascade (Ramsammy et al., 1988a), an effect that localizes the site of interaction at the cytoplasmic surface of the plasma membrane and most likely reflects binding of the polycationic gentamicin to the polyanionic phospholipid, phosphatidylinositol-4,5-bis-phosphate
