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Instead, the authors propose that intracellular copper mislocalization and defective copper handling, rather than absolute copper load, drive cellular stress and barrier disruption

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1 H NMR (300 MHz, DMSO) 9.14 (s, 1H), 7.87 (t, J=5.2 Hz, 1H), 7.38-7.14 (m, 15H), 6.92 (d, J=8.2 Hz, 2H), 6.64 (d, J=8.2 Hz, 2H), 3.14-3.03 (m, 2H), 2.73 (s, 2H), 2.54 (2H), CH 2 protons merged with a DMSO-d 6 peak

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THCV also induced a reduction in weight and hypophagia at doses as low as 3 mg/kg