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Alternatively, extracellular NAD + can be utilized by NAD + glycohydrolases, generating NAM, NR, or NMN outside of the cells, which can then be transported intracellularly for NAD + synthesis 65,66

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H 2 -receptor antagonists: include cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), and ranitidine (Zantac)